ABSTRACT: New biological information concerning host-plant associations and/or significant geographical distributions are presented for 16 species of Cerambycidae from the Great Plains ecosystem in the following genera: Ataxia, Crossidius, Dectes, Ecyrus, Mecas, Megacyllene, Oberea, Sternidius, Tetraopes, and Urgleptes. Season-long phenological data are presented for two sympatric four-eyed milkweed beetles, Tetraopes femoratus and Tetraopes tetrophthalmus. The distribution of Tetraopes pilosus is influenced by soil type and characterizations of the habitat are given based upon soil associations.